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Similarly, a diet lacking in fiber can cause constipation, which leads to straining that puts extra pressure on the veins in the abdomen and lower legs

Dox-loaded AuNPs, which were non-toxic toward normal mouse fibroblast (L929) cells, also demonstrated selective toxicity toward fibrosarcoma tumors in mice [129]

Third, clinical translation should include establishing multicenter ALS biobanks to validate associations between biomarkers such as ACSL4 and GPX4 and clinical measures including ALSFRS-R scores and survival, and conducting combined trials of ferroptosis inhibitors with mitochondrial protectants to evaluate therapeutic benefit in sporadic ALS

PLoS ONE 15 , e0241989 (2020)