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In NHPs receiving SC infusions of 0.5 mg/kg/24 h of setmelanotide, the efficacious dose for DIO NHPs determined by Kievit et al., a C max of approximately 150 ng/mL was reached within the first two hours and persisted for the duration of the treatment, resulting in an AUC 24 h of 3814 ng x h/mL (45, 95)

doi: 10.4110/in.2011.11.1.59 188 LangmeadLMakinsRJRamptonDS

10.1139/apnm-2017-0724 Appl Physiol Nutr Metab

Tip: Conclusion You have a comprehensive grasp of the lip's neurovascular anatomy, including the motor innervation from the facial nerve branches, sensory input from trigeminal branches, and blood supply from the labial arteries