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142 HFD-fed mice exhibit substantial accumulations of senescent CD4+ T cells in visceral adipose tissue, contributing to local inflammation via elevated pro-inflammatory factor expression

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Injection site reactions occurred in 1015% of participants, slightly more than with semaglutide alone

If the proposed mechanism (gradual synaptic plasticity effects) is right, daily dosing might be needed for sustained effect

Collectively, the physicochemical-optimized nanoparticles can be designed as a highly promising platform for effective anti-Alzheimer's drug delivery, in which, within this criteria window, nanoparticles exhibit (i) prolong systemic circulation time, reducing rapid clearance by immune system and enhance passive targeting due to the pathology of AD (Snchez-Lpez et al., 2018