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ET and WR worked on the data analysis and revisions of the manuscript

Ischemia also triggers the depolarization of the mitochondrial membrane, resulting in excessive ROS production, decreased ATP generation and PTEN-induced putative kinase 1 accumulation (Lazarou et al., 2015)

These co-localization results demonstrated that cisplatin-induced mitochondrial ROS (mROS) generation is associated with mitochondrial deterioration in HK-2 cells