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G.MartinA.et al (2022)

The dosage for each drug across all groups was standardized at 5 mg/kg to ensure consistency in the assessment

doi: 10.3109/08830180903215613 210 S-PereiraI.BritesD.BritoM

Antiepileptic drugs prescribed to people with seizure disorders

In this model system, when we performed cytotoxicity assays in the presence or absence of 10 M valspodar, a P-gp inhibitor, we observed that P-gp overexpression conferred resistance to imidazole ketone erastin, piperazine erastin, and FIN56, and that valspodar reversed the resistance