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Although an older study of perfused rabbit hearts showed no reduction in the damage caused by reperfusion following ischaemic insult (Reference Cargnoni, Bernocchi and Ceconi86) , more recent work in diabetic rats showed that 6 weeks of ergothioneine supplementation resulted in decreased biomarkers of cardiac injury, lipid peroxidation and inflammation (Reference Dare, Elrashedy and Channa87)