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Results Si-based agent showed efficacy in relieving the symptoms of UC To examine whether the Si-based agent prevents the worsening of UC, we generated 5% DSS-induced UC model mice and performed a comparative analysis between the UC model mice fed with 2.5% Si-based agent-containing diets (Si-DSS group) and those fed with diets without the Si-based agent (Con-DSS group)

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The proposed new measures and the timeline for incorporating the measures into the APP Plus quality measure set are described in section IV.A.4.c.(3) of the CY 2025 PFS proposed rule and below

Specifically, sulforaphane increases the BMP-7 expression through inhibiting the activating of HDAC2, activates Smad1/5/8, and suppresses the TGF-/Smad pathway, thereby mitigating renal fibrosis