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The manuscript highlights how DDSsincluding stimuli-responsive nanoparticles, targeted ligands, and biodegradable carriersenhance solubility, bioavailability, and tissue-specific delivery of urate-lowering agents (e.g., allopurinol and febuxostat) and anti-inflammatory therapies (e.g., colchicine and IL-1 inhibitors) (Liu S

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Nature 525 , 528532 (2015)

In addition to VDAC, which is predominantly localized to mitochondria, several highly enriched resident MAM proteins have been demonstrated to play a key role in mitochondrial cholesterol transport