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4a) G6PD is commonly overexpressed in many myeloid and lymphoid malignancies leading to improved proliferation, but this effect can be abrogated by pharmacologic inhibition of G6PD 87

They generate superoxide (NOX1-3, NOX5) or hydrogen peroxide (NOX4, DUOX1-2) through an NADPH-dependent mechanism [Magnani & Mattevi, 2019]

Synergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity