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However, challenges persist in standardizing isolation methods (e.g., ultracentrifugation, immunoaffinity) and scaling production without compromising vesicle integrity [329]

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DeWitte et al reported pancytopenia and severe immune deficiency in a preterm infant whose mother received 125 mg azathioprine and 12.5 mg prednisone daily.5 There have been two published reports of abnormal physical findings

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