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Despite several studies indicating the therapeutic effects of ferroptosis inducers for treating RA patients, some studies have suggested that inhibition of ferroptosis may improve the symptoms of patients with RA

Tian F, Lee SY, Woo SY, Chun HS (2020) Alternative oxidase: a potential target for controlling aflatoxin contamination and propagation of aspergillus flavus

These lipases are activated by high epinephrine and glucagon levels in the blood (or norepinephrine secreted by sympathetic nerves in adipose tissue), caused by declining blood glucose levels after meals, which simultaneously lowers the insulin level in the blood

While historically used for hypertension and neuropsychiatric conditions, it has been associated with side effects including lethargy, sedation, depression, and other psychiatric symptoms when used at doses above 0.5 mg/day [37]