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Acknowledgments We thank the UK Biobank study, and the summary statistics data of UKB can be download from Neale lab ( and other GWAS summary-level data, which have been downloaded from We also thank all the reviewers and editors for their useful suggestions for improving this study

The goods offered by the Seller include chemical substances that shall not be used as a drug, medicine, active substance, medical aid, cosmetic product, a substance for production of a cosmetic product neither for human consumption that is any food or food supplement or otherwise similarly used on humans or animals

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Step 6 Scale-Up Validation & Stability Stress Testing The final formulation undergoes accelerated stability testing (temperature, light) and compatibility checks with common cosmetic excipients