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In vivo, M1 macrophage exosomes with low miR-663b expression attenuated pulmonary vascular remodeling in PH rats, suggesting that exosomal miR-663b exacerbates PASMC dysfunction and PH progression by suppressing the AMPK/SIRT1 axis and promoting inflammation

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Figure 1 2.1 The mechanism of ferroptosis 2.1.1 The GPX4/GSH signaling pathway in ferroptosis GSH is the primary antioxidant involved in intracellular antioxidant stress, participating in numerous essential cellular metabolic activities such as the removal of ROS, DNA and protein synthesis, and signal transduction

An Injectable Solution Of Vitamins b12, b1 , b2, and b6 for the stimulation of appetite to increase food intake and to improve general condition