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Moreover, because circulating LCAC levels often correlate with disease severity, NYHA class, and are reduced by surgical intervention, continued monitoring of a CVD patients metabolome could provide insight into the progression or regression of the disease ( 2+ overload mediated by the acylcarnitines [reviewed by Besides CVD, developing a greater understanding of cellular LCAC pathogenesis will be informative for the disease processes of rare, but often lethal, fatty acid oxidation and carnitine metabolism disorders ( Conclusion This review addressed the existing basic science investigations into the direct effects of the amphiphilic metabolites, LCACs, on cardiac function

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It is also possible that HPA sensitivity rather than HPA axis dysfunction exists in patients (63)

In casein, hydrolysis is enhanced in the substrate, which is evident by the presence of NH, OH, amide, and CO

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