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The mice supplemented with leucine exhibited an upregulation in the relative abundance of Hippo-related genes, and their hepatic injury was more pronounced after APAP injection

p=0.09), and higher age (63.2 versus 52.4 years

In 2008, Narendra et al (37) discovered that Parkin, an E3 ubiquitin ligase, is involved in mitochondrial depolarization and recruited to accelerate mitochondrial autophagic degradation