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ROS, as natural metabolic byproducts, have been shown to damage nucleic acids, proteins, and lipids through mechanisms such as DNA mutations, lipid peroxidation, and altered post-translational modifications, ultimately compromising cellular integrity

J Alzheimers Dis 66:517532 Matsuzawa D, Obata T, Shirayama Y, Nonaka H, Kanazawa Y, Yoshitome E, Takanashi J, Matsuda T, Shimizu E, Ikehira H, Iyo M, Hashimoto K (2008) Negative correlation between brain glutathione level and negative symptoms in schizophrenia: a 3T 1H-MRS study