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The first is that Eli Lilly was expecting greater non-diabetic weight loss with orforglipron based on phase 2 trials, and that apparently never happened for reasons that are still unclear

[DOI] [PMC free article] [PubMed] [Google Scholar] 57.Baker G.J., Yadav V.N., Motsch S., Koschmann C., Calinescu A.A., Mineharu Y., Camelo-Piragua S.I., Orringer D., Bannykh S., Nichols W.S., et al

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[DOI] [PubMed] [Google Scholar] 5.Durward, A., and Rudall, K.M