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It has been hypothesized that reduced GHK-Cu availability may impair tissue repair, antioxidant defense, and cellular communication, thereby contributing to the phenotypes associated with cellular aging

2023;11(11):e1060

Vascular smooth muscle cells need to proliferate and synthesise new matrix components for effective repair

609 A randomized controlled crossover trial in 60 men with stage 1 hypertension found 6 mg hydroxytyrosol plus 136 mg oleuropein (another olive polyphenol) daily for six weeks significantly reduced blood pressure and total cholesterol, LDL-cholesterol, and triglyceride levels compared with a polyphenol-free supplement

doi: 10.1016/j.cbi.2012.12.017 Summary Keywords diabetes, retina, oxidative stress, polyunsaturated fatty acids, lipid peroxidation, aldehydes, advanced lipoxidation end products, detoxification Citation Augustine J, Troendle EP, Barabas P, McAleese CA, Friedel T, Stitt AW and Curtis TM (2021) The Role of Lipoxidation in the Pathogenesis of Diabetic Retinopathy