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Notably, this combination exerts additive or synergistic actions by targeting distinct neuroendocrine pathways: cagrilintide modulates homeostatic and hedonic food regulation centers in the hindbrain and hypothalamus, while semaglutide engages central and peripheral GLP-1 pathways to reduce calorie intake and improve glycemic regulation

The extracts contain several constituents that can influence the bioavailability and pharmacokinetic parameters of the marker compounds

[DOI] [PubMed] [Google Scholar] 47.Meunier B, de Visser SP, Shaik S

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