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In vitro studies using MDCK cells (a model of intestinal epithelial permeability) demonstrated that PLGA nanoparticles significantly enhanced cellular uptake and transport of puerarin across cell monolayers, achieving a permeability coefficient value of 2.83 0.27 10 5 cm/s, which was significantly higher than that observed for free puerarin (0.38 0.07 10 5 cm/s)

A multicenter Phase III clinical trial confirmed that elagolix significantly reduces menstrual blood loss associated with uterine fibroids, with efficacy unaffected by age, body mass index, ethnicity, baseline bleeding volume, or fibroid location [160]

While IGF-1 LR3 offers potential benefits for muscle, metabolism, and even skin health, it also carries significant risks that clinicians must discuss with patients

ultrasound and hot water extraction enhanced activity, suggesting that production methods can influence bioactivity (Hasheminya et al., 2020)