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have reported abnormally enhanced complex I activity in mitochondria obtained from a skeletal muscle biopsy of an ASD patient [73]

Lifetime risk of LS-related EC is associated with age and a mutation of a specific MMR gene

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Janus-faced amyloids: protectors and perpetrators in Neuro-PASC Controversial and disappointing results from two phase 3 trials of the monoclonal antibody, aducanumab that targets the reduction of insoluble A [324327], implies that merely suppressing or inhibiting the formation of insoluble A may not fully address the complex, multi-faceted functions of amyloid aggregation that drive the progression of AD and other neurodegenerative disorders

A nice example for a steric hindrance-mediated kinetic insulation is the periplasmic disulfide shuttle system (Fig