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GPR-105 antagonists e.g., such as those disclosed in WO 2009/000087 SGLT inhibitors e.g., ASP1941, SGLT-3, SGLT-2 such as empagliflozin, dapagliflozin, canagliflozin, and ertugliflozin, BI-10773, remogloflozin, TS-071, tofogliflozin, ipragliflozin, and LX-4211 inhibitors of acyl coenzyme A carboxylase ACC, MK-4074 inhibitors of diacylglycerol acyltransferase 1 and 2 DGAT-1 and DGAT-2 inhibitors of fatty acid synthase inhibitors of acyl coenzyme A:monoacylglycerol acyltransferase 1 and 2 MGAT-1 and MGAT-2 agonists of the TGR5 receptor galectin 3 inhibitor e.g