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Although astrocytes can utilize fatty acids as an alternative energy source, prolonged reliance on lipid oxidation results in oxidative stress and mitochondrial impairment, exacerbating neurodegeneration 82

Iron is imported via endocytosis of Fe 3+ -loaded Tf, or via DMT1 for non-transferrin-bound iron (NTBI), and the zinc transporter protein, SLC39A14, and stored in the labile iron pool (LIP) or as ferritin [23]

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The same enzymes designed to break down dietary protein into amino acids

These DNA-damage recognition proteins have been shown to deliver signals from DNA breaks to downstream proteins such as p53, p73 and mitogen-activated protein kinases (MAPK), which activate apoptosis and other forms of cell death [21]