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Wenting He, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

& Richards, P

This multifaceted predisposition for stroke can be attributed, at least in part, to the activation of endothelial cells, which undergo a transformation from an anticoagulant to procoagulant phenotype

On the other hand, chronic inflammation is believed to contribute to a variety of diseases, such as cancer, diabetes and heart disease

Interstitial fibrosis further induces ischemia and hypoxia by impairing capillary to tubule diffusion, creating a vicious cycle and exacerbating renal injury (43)