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Este equilibrio redox regula diversos procesos metablicos intracelulares que incluyen la actividad enzimtica, el transporte celular, transduccin de seales y la expresin gnica mediada por la transcripcin de factores entre los que se destacan el activador de protena (AP-1), el factor nuclear kappa-p ( NF k-B) y el p53 (4)(26)(33)

Hypoxia Inhibitor Improves Iodine Uptake Disorder in Thyroid Cancer Through the hsa_circ_0023990/miR-448/DNMT1/NIS Axis

En particular, la magnitud de la reduccin de GSH parece ser paralela a la gravedad de la enfermedad

Understanding these shared mechanisms may help clarify inconsistencies across studies and reveal new therapeutic opportunities

Secondly, HOCl/OH can activate enzyme complexes involved in DNA repair (such as APE1, PARP, DNA ligase) to assemble at DNA damage sites, promoting chromatin decondensation and further enhancing NETs/NETosis [247]