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More significant changes to body composition, such as increased lean body mass and fat loss, typically become apparent after three to six months of consistent use

we also include un-normalized data in Supplementary Fig

Waring RH, Emery P

Cyclin-dependent kinases (CDK2, CDK4, CDK6) and their inhibitors, such as p21, p27 and p53 [60, 64] and downregulation of Rb phosphorylation [65, 66] also mediate the growth-suppressive effects of this agent