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A phase I study of indoximod, another IDO inhibitor, in combination with docetaxel, an antimitotic chemotherapy drug, showed stable or partially stable disease conditions in more than 50% of patients [132]

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Both insulin and IGF-1 modulate CD4 + T cell metabolism Both insulin and IGF-1 alter the metabolism of metabolic cells and tissues, with insulin particularly well known for increasing glucose uptake 1,9,13

Notice that I did not mention any downsides in terms of safety

Mol Cancer Ther 5:19952006