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For directly lightening dark spots, hydroquinone is usually the more targeted choice because it blocks melanin production

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Low GSH, neutrophil infiltration, myeloperoxidase activity and inflammation increase oxidative stress overwhelming the antioxidant defense, and hypochlorous acid mediated GSH oxidation and its attachment to proteins contribute to further GSH deficiency (114)

Lanthanide ions have the ability to absorb NIR light and convert them to higher energy photons effectively