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The 2024 fusion-peptide work exists precisely because researchers recognized that native DSIPs delivery to the brain is the bottleneck, and engineered around it by fusing DSIP to a blood-brain-barrier-crossing TAT transduction domain (sequence GGGGYGRKKRRQRRR) via flexible GGGGS linkers, expressed and secreted from Pichia pastoris

Two peptides with complementary mechanisms in a single formulation

The GHK-Cu group showed significantly greater total protein and collagen synthesis demonstrating that the peptide's effects on extracellular matrix accumulation extend to systemic injection, not just topical application

In turn, this excess iron triggered both a hyperproliferation of skin cells and an abnormally high concentration of inflammation-inducing neutrophils (a type of immune system cell) in the topmost layer of skin

Metformin, a common diabetic drug is also a cause of B12 deficiency