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The reduction in swelling also reduces the risk of further complications, such as infections or tissue damage, which are common concerns in patients with diabetic neuropathy

Simulations suggested that this microsphere formulation could allow for once-monthly human dosing while maintaining effective drug levels, potentially reducing adverse side effects

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These limitations underscore the urgent need for regenerative therapies that go beyond symptomatic management to actively restore skin integrity and immune balance

Future work should further deepen research into cell death mechanisms (especially pyroptosis and ferroptosis) and inflammatory/oxidative stress pathways, refine preclinical models to better mimic human conditions, and conduct large-scale clinical cohort studies to validate potential therapies