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Also, chronic oxidative stress causes a buildup of misfolded proteins in the endoplasmic reticulum (ER), triggering ER stress and activating the unfolded protein response (UPR) that intensifies mucus production and contributes to the development of chronic inflammation (198200)

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The Pineal Gland: a neurochemical transducer: chemical signals from nerves regulate synthesis of melatonin and convey information about internal clocks