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When 6-week-old pigs were fed a diet with oxidized fat (rapeseed oil that had been heated to 175C for 72 h) for 29 days, mRNA concentrations in Nrf2 target genes, including NAD(P)H dehydrogenase, quinone 1, peroxiredoxin 6, glutathione peroxidase 2 and thioredoxin reductase 1 in the duodenal mucosa, were upregulated (Ringseis et al

Initial blood tests typically include: Serum B12 measurement : The first-line investigation, though reference ranges vary between laboratories

Single-gene markers Certain genes that play key roles in the ferroptosis pathway may also serve as independent prognostic indicators based on their expression levels

doi: 10.1038/srep42394 76 ZhangYLiuLJinLYiXDangEYangYet al

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