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Mitochondrial iron detoxification is a primary function of frataxin that limits oxidative damage and preserves cell longevity

Additionally, PD-1 synergistic effects with immune checkpoint receptors like T cell immunoglobulin and ITIM domain (TIGIT) significantly enhance Tregs function and promote T-cell apoptosis, which together leads to the formation of a T-cell depleted state

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The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis