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Third, the main limiting factor is that the main CNS pharmacokinetic principles are not followed during the evaluation of drug delivery efficacy of nanocarriers and (pro)drugs, which leads to inaccurate interpretation of the results or inadequate investigation of the brain delivery of drugs

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[10] Due to the potential for harmful drug interactions and other serious adverse effects, oral ketoconazole should only be used to treat serious fungal infections when no other antifungal therapies are available