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10.1016/S0092-8674(04)00130-8 65 ChiuC

The role of heme oxygenase-1 promoter polymorphisms in human disease

That said, the clinical evidence for routine 5-MTHF in over-35s without an MTHFR polymorphism remains limited, and folic acid at the 400 g dose remains the guideline-backed default