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Thiamine deficiency in causes neurological injury leading to the Wernicke/Korsakoff syndrome ( FIGURE 2 via effects on homocysteine/methionine metabolism as well as DNA methylation

Peptide inhibitors or antagonists of cell surface proteins Immune checkpoint inhibitors The advent of immune checkpoint inhibitors (ICIs) has revolutionized the field of tumor therapy and promoted the development of more immune checkpoint blockades 83

The above-cited studies report that Curcuma longa and its active metabolites, through multi-target regulation of inflammatory responses and BBB protection, may provide a novel strategy for the pathological intervention of brain edema in hypoxic environments at high altitudes

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Mean daily Depakote ER doses for observed cases were 2362 mg (range: 500-4000), 2874 mg (range: 1500-4500), 2993 mg (range: 1500-4500), 3181 mg (range: 1500-5000), and 3353 mg (range: 1500-5500) at Days 1, 5, 10, 15, and 21, respectively