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It enables us to localise pain, to measure its duration, and to verify the existence of the characteristic refractory period observed in TN.5 We must also assess any accompanying symptoms, including autonomic signs (conjunctival injection, tearing, rhinorrhoea), which are less pronounced and briefer than those observed in short-duration trigeminal autonomic cephalalgias, such as short-lasting unilateral neuralgiform headache attacks (SUNCT) and short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA).39,40 In the medical history interview, painful trigeminal neuropathy is described as continuous or near-continuous pain, without the predominance of painful paroxysms observed in TN

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The sequence of primer pairs used for RT-PCR were listed as below: mCol1A1 forward 5-AGCCGCAAAGAGTCTACATG-3, reverse 5-CTTAGGCCATTGTGTATGCAG-3

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