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These results suggest that GSH, either directly or indirectly, is responsible for reducing PDI enzymes and that this low molecular mass thiol can efficiently pass across the ER membrane

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Biotransformation of Curcumin through Reduction and Glucuronidation in Mice

Their strategy was to exploit the propensity of a cysteine residue (Cys598) in the Saccharomyces cerevisiae transcription factor, Yap1, to condense with the sulfenic acid intermediate formed at Cys36 of the redox sensing protein, Orp1 (also known as Gpx3)

However, the method for obtaining BMSCs is invasive, the sample size for clinical treatment is relatively limited, and the long-term efficacy is unknown, warranting further research