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Animal studies administering 5-Amino-1MQ orally to diet-induced obese mice have shown dose-dependent reductions in body weight (typically 10-30% reduction compared to vehicle-treated obese controls over 4-12 week treatment periods), with the weight loss primarily reflecting fat mass reduction while lean mass is preserved or even increased

Beneficial effects of peroxynitrite decomposition catalyst in a rat model of splanchnic artery occlusion and reperfusion

It has also been studied for its role in protecting cells from oxidative stress and supporting retinal and neurological health

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These findings have provided a novel mechanistic insight into the role of GSTM1 in astrocytes as a critical modulator of brain homeostasis during inflammatory responses