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10.1016/j.jalz.2019.07.002 268 LiG.LiuX.SunX.HuangL.KuangW.OuJ.et al

This process occurs through the direct binding of RSL3 to USP11, resulting in its inactivation and subsequent induction of ubiquitination and degradation of NRF2 protein in these cells [122]

Its mechanism is focused squarely on the pituitary gland

Neuroinflammation Neuroinflammation is increasingly recognized as a key factor interacting with neurobiological correlates of the neuropsychiatric long COVID syndrome, such as brain serotonin depletion [111], hypothalamicpituitaryadrenal (HPA) axis dysregulation [57], and impaired hippocampal neurogenesis and plasticity [13, 61]