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Studies also suggest that the changes in biological sex- and sex hormone-mediated memory circuitry become evident in midlife and during aging (247)

The phase Ib TROPION-Lung02 trial is a dose-escalation and -expansion study evaluating Dato-DXd (4 or 6 mg/kg) combined with pembrolizumab (doublet) with or without platinum agents (triplet therapy) in both previously untreated and pre-treated patients with metastatic NSCLC without actionable genomic alterations

doi:10.1016/j.cotox.2017.10.008

We initially induced oxidative stress through intraperitoneal injection of DQ, leading to a reduction in serum antioxidant capacity