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C: Common appearance resulting from repeated hemorrhage and accumulation of hemosiderin-laden macrophages

With age, WAT/body weight ratios increased in WT mice (0.8 +/- 0.1% young, 4.1 +/- 0.3% old) and Has1,3 dko mice (0.8 +/- 0.01% young, 2.3 +/- 0.2% old) but this increase was 44% less in old Has1,3 dko mice

Collagen loss with age

HSP90 inhibitors Heat shock protein 90 (HSP90) is a chaperone involved in cellular homeostasis in different physio-pathological conditions, such as cancer

Conclusion and future directions In conclusion, COVID-19 has presented unique and significant challenges for patients with anemia and hematological malignancies, who face a higher risk of severe illness and mortality