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Although clinical research on gut microbiomes in PD patients remains limited in scale, further studies may validate the use of probiotics, prebiotics, and synbiotics

Within this framework, the human HMC3 microglial cell line has emerged as a widely used in vitro model to investigate microglia-driven processes, including neuroinflammation, oxidative stress, neurodegeneration, and tumor-associated pathology

To measure collagen deposition, selected sections were stained with Massons trichrome

In conclusion, Tf-modified drug delivery systems present considerable advantages in the management of CNS disorders