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Abbreviations AS: artesunate CI: combination index DMSO: dimethylsulfoxide iFBS: heat inactivated fetal bovine serum NAC: N-acetylcysteine NTS: newly transformed schistosomula PI: propidium iodide PZQ: praziquantel RESV: resveratrol TEM: transmission electron microscopy References Steinmann P, Keiser J, Bos R, Tanner M, Utzinger J

Taken together, FOXO4-DRI is able to remove the senescent cells in PDL9 chondrocytes, but its utility in promoting cartilage formation from the in vitro expanded chondrocytes needs further investigation Given that FOXO4 expression may be a biomarker for postmenopausal osteoporisis, perhaps the founding researchers were onto something with their discovery

Strategically, this approach reframes osteoarthritis as a dynamic, potentially modifiable process, especially in early or post-traumatic stages

In contrast, when tissue folate or cobalamin stores are intact (Silberberg et al, 1997) or in the case of an alteration of the transsulfuration pathway dependent on vitamin B 6 deficiency or on heterozygosity for a CBS defect (Bostom et al, 1995a), an excessive methionine supply might lead to an important elevation of plasma homocysteine

A: Some studies suggest activity when administered orally or via injection in animal models, but this is still under investigation and not clinically validated