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Some suppression of natural testosterone production still occurs, particularly with more suppressive compounds like RAD-140 and LGD-4033, which is why PCT is necessary for most cycles

A recent review found that nicotine-based e-cigarettes increased quit rates by 59 percent compared to nicotine replacement therapy, and by 46 percent compared to non-nicotine e-cigarettes (210)Lindson N, et al

However, its use in the general population for weight management or body composition enhancement is not supported by sufficient evidence and falls outside its licensed indications in all countries where it holds authorisation

The necessity and intensity of PCT depends on what compounds were used, for how long, and at what doses

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