Although milk thistle has demonstrated hepatoprotective effects in rats (2), further research is needed to establish similar success in humans
Methods: A descriptive observational study was conducted at Bachmai Stroke Center between December 1, 2023, and August 31, 2024, enrolling minor ischemic stroke patients (NIHSS scores 5 and items 1a, 1b, and 1c on the NIHSS scale = 0) hospitalized within 24 hours of symptom onset and had END (defined as a rise of 2 points in the NIHSS score during the first 72 hours after admission)
If required, gentle heating or sonication may be used to support dissolution
How pregnancy affects APD symptoms Some women experience worsening skin or allergic symptoms , particularly early in pregnancy Others report symptom improvement or complete remission , possibly due to gradual progesterone increases and immune tolerance In some cases, APD may first appear during pregnancy or after childbirth , potentially due to immune sensitization during gestation Management during pregnancy Antihistamines are often used to control histamine-mediated symptoms and are commonly part of pregnancy-safe treatment plans Progesterone desensitization may be considered before conception or early in pregnancy for those with severe reactions Close monitoring allows clinicians to balance symptom control with fetal safety Postpartum considerations Symptoms may recur or worsen after delivery , when progesterone levels drop rapidly Ongoing follow-up is important to manage postpartum flares and guide future family planning With individualized care and proactive planning, many people with autoimmune progesterone dermatitis are able to conceive, maintain pregnancy, and deliver safely
Fibroblast heterogeneity: implications for human disease
