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So the first honest distinction is structural: tesamorelin is a modified full-length analog engineered for resistance to degradation, whereas sermorelin is an unmodified short fragment that reproduces GHRH activity but not GHRH stability

the method comprises reacting a first lipid-containing conjugation partner comprising a carbon-carbon double bond, a second lipid-containing conjugation partner a carbon-carbon double bond, and an amino acid-comprising conjugation partner comprising a thiol, under conditions effective to conjugate the first and second lipid-containing conjugation partners to the amino acid-comprising conjugation partner

Chemosphere 61:276281

Malcolm A

Psychiatry 76 , 550558 (2014)