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216 In addition, PRMT4-catalyzed asymmetric dimethylarginine (ADMA) has been reported to bind to NOS as a ligand, leading to NOS dysfunction, resulting in decreased cerebral blood flow and aggravating AD, which can be reversed by inhibition of PRMT4

On the contrary, Bacteroides , Parabacteroides , FP , Clostridium leptum , and Prevotella were significantly decreased, and there was a 50% reduction in the high butyrate producer FP (205)

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Phase IIb and Phase III trials showed it did not meet primary endpoints for weight loss versus placebo

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