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Ferroptosis in degenerative diseases is unlikely to be driven by a single event such as iron excess

For example, Nadatani in 2016 reported that caspase-1 can induce pyroptosis, a unique form of programmed cell death, through the conversion of pro-IL1 and pro-IL18 in their active forms, which promotes further inflammation

Similarly, the activity of the selenium-containing glutathione peroxidase enzyme, responsible for speeding up the reaction between glutathione and free radicals (such as hydrogen peroxide) will be negatively affected if dietary selenium is low and enhanced when selenium is high

This "episode" we'll call it went on for as long as it could until he won the battle and finally got past it

10.1016/j.freeradbiomed.2015.04.036 37 DjouadiF.AubeyF.SchlemmerD.BastinJ