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A case in point, when 2 different mouse strains were exposed to therapeutic or hepatotoxic doses of APAP, depletion of GSH or APAP protein adduct formation was only detected in the liver but not in the whole brain or individual brain regions, suggesting that there is no evidence for the formation of the reactive metabolite NAPQI in the brain of adult mice [185]

doi: 10.1016/j.tem.2019.05.008

doi: 10.1111/ene.12846

Skin whitening may occur if melanin synthesis is reduced

Brains were subsequently embedded in the Optimal Cutting Temperature (OCT) compound and sectioned into 30-m-thick coronal prefrontal slices using a CM1860 Cryostat (Leica, Germany)